David Richard Matthews

Professor of Diabetic Medicine, University of Oxford, United Kingdom and Medical Tutor at Harris Manchester College, United Kingdom

Contact details
Telephone: (PA) 01865 271015
GMC number 2223940
Email: david.matthews(@)ocdem.ox.ac.uk

Employment History


  • Professor of Diabetic Medicine, Nuffield Department of Clinical Medicine, University of Oxford
  • Tutorial and Governing Fellow of Harris Manchester College, Oxford
  • Co-Director of the UK Diabetes Research Network
  • NIHR Senior Investigator
  • Director of the Oxford Health Alliance
  • Emeritus Founding Chairman, OCDEM

Other appointments (current):

  • Hon Consultant Physician, Oxford Radcliffe Hospitals.
  • Founding Trustee and Director, Oxford Health Alliance (OxHA)
  • EASD Council member
  • EASD Chairman of Panel on Global Statements
  • Chair and founding lead, Robert Turner Research Course (EASD)
  • Chair of Advisory Committee, Diabetes Research and Wellness Foundation
  • Chair of Appointment Committee, Novo Nordisk Foundation
  • Co-chairman of the CANVAS trial
  • Co-Chair and lead of the VERIFY trial
  • Editorial Board, Diabetic Medicine
  • Editorial Board, European Journal of Clinical Pharmacology
  • Editorial Board, Diabetes & Vascular Disease Research
  • Lay Preacher, Methodist Church
  • Member of the Methodist Church Council

Other appointments (past):

  • Founding Chairman, Oxford Centre for Diabetes, Endocrinology and Metabolism.
  • Executive Director Global Alliance for Chronic disease.
  • Vice Principal, Harris Manchester College, Oxford.
  • Member of UKPDS Policy Advisory Board, Executive committee; chair of endpoints committee
  • Chairman, Methodist Relief and Development Fund
  • Founding and organising Chairmen of the Annual Oxford Symposium
  • Chairman of the Central Oxford Research Ethics Committee.
  • Trustee, Diabetes UK.
  • Social responsibility board of the Methodist Church: committee on health and healing.
  • Secretary of the European Association for the Study of Diabetes’ workshop group: Artificial Insulin Delivery Systems and Pancreatic and Islet Transplantation.
  • Chairman of Diabetes UK research grants committee
  • Board of Trustees, Diabetes UK, by election
  • Member Regional A+B award committee
  • Consultant Physician, Oxford Radcliffe Hospital NHS Trust

Academic Awards (all awarded in open competition):

  • Senior Scholar, Corpus Christi College, Oxford, 1970
  • Medical Research Council Scholar, 1970
  • Nuffield Junior Research Fellow, Balliol, Oxford, 1981
  • Joan and Richard Doll Senior Research Fellow, Green College, 1984
  • University of Oxford, Reader in Diabetic Medicine, 2000
  • University of Oxford, Professor of Diabetic Medicine, 2002

Invited Lectures:

I have lectured widely, including many invited lectures and state-of-the-art lectures on the subjects of the World Pandemic of diabetes, insulin resistance and ß-cell failure, mathematical modelling, the incretin axis and GLP-1, pulsatile insulin secretion, the aetiopathology of non-insulin-dependent diabetes, the analysis of pulsations in endocrinology, medical ethics, theology and chaos, lipids, and the care of the terminally ill. I gave the Banting Lecture at Diabetes UK (their most prestigious lecture) in 2010 on the subject of type 2 diabetes viewed as an infectious disease.

Academic Research Interests:

  • The world pandemic of type 2 diabetes: founding director and trustee of the Oxford Health Alliance, a group co-ordinating activity in the prevention and containment of the epidemic.
  • Type 2 diabetes: including mathematical modelling of insulin resistance and the analysis of pulsatile insulin (and other hormones, especially Growth Hormone) using time-series analysis.
  • Insulin resistance and beta-cell failure: HOMA model of beta-cell function and insulin resistance: (described first by us in 1985) and now widely used in epidemiology and in 2013 iHOMA (Published in Diabetes Care)
  • We have developed the concept of the Coefficient of failure to allow comparisons between trials aimed at preservation of beta-cell function
  • Trials: deputy co-ordinator and member of the Executive and Policy Advisory Committees of the UK Prospective Study of Diabetes (UKPDS). Co-author on many major papers. The UKPDS is the basis for much of the evidence-base for the treatment of type 2 diabetes, and was the largest study in type 2 diabetes ever undertaken.
  • Glucose and Ketone sensing in hand-held meters: our work is the basis of the published guidelines for home-ketone sensing.
  • Therapeutic agents in type 2 diabetes: studies using sulphonylureas, thiazolidinediones, GLP-1, and insulin.
  • Retinopathy: especially in type 2 diabetes.
  • Dynamic insulin theory
  • Long-acting and short-acting insulin in man
  • Pulsatile insulin secretion in man
    • We were the first group in the world to describe insulin oscillations using time-series analysis and pioneered the use of Fourier analysis in short signals for use in endocrinology research. We have now developed a suite of time-seris analysis programmes (Graph++) for use in this field.
  • Growth Hormone secretion: its analysis and physiology.
  • GLP-1 and the incretin axis.
  • The history of diabetes an oral history project. Funded (twice) by the Wellcome trust

Academic and Clinical Work:

Teaching: Medical Tutor, Harris Manchester College.

Co-ordinator of several courses including the EASD Robert Turner Clinical Training course, and the Oxford Steno clinical training course.