Professor of Diabetic Medicine, University of Oxford, United Kingdom and Medical Tutor at Harris Manchester College, United Kingdom
Contact details
Telephone: (PA) 01865 271015
GMC number 2223940
Email: david.matthews(@)ocdem.ox.ac.uk
Employment History
Current:
- Professor of Diabetic Medicine, Nuffield Department of Clinical Medicine, University of Oxford
- Tutorial and Governing Fellow of Harris Manchester College, Oxford
- Co-Director of the UK Diabetes Research Network
- NIHR Senior Investigator
- Director of the Oxford Health Alliance
- Emeritus Founding Chairman, OCDEM
Other appointments (current):
- Hon Consultant Physician, Oxford Radcliffe Hospitals.
- Founding Trustee and Director, Oxford Health Alliance (OxHA)
- EASD Council member
- EASD Chairman of Panel on Global Statements
- Chair and founding lead, Robert Turner Research Course (EASD)
- Chair of Advisory Committee, Diabetes Research and Wellness Foundation
- Chair of Appointment Committee, Novo Nordisk Foundation
- Co-chairman of the CANVAS trial
- Co-Chair and lead of the VERIFY trial
- Editorial Board, Diabetic Medicine
- Editorial Board, European Journal of Clinical Pharmacology
- Editorial Board, Diabetes & Vascular Disease Research
- Lay Preacher, Methodist Church
- Member of the Methodist Church Council
Other appointments (past):
- Founding Chairman, Oxford Centre for Diabetes, Endocrinology and Metabolism.
- Executive Director Global Alliance for Chronic disease.
- Vice Principal, Harris Manchester College, Oxford.
- Member of UKPDS Policy Advisory Board, Executive committee; chair of endpoints committee
- Chairman, Methodist Relief and Development Fund
- Founding and organising Chairmen of the Annual Oxford Symposium
- Chairman of the Central Oxford Research Ethics Committee.
- Trustee, Diabetes UK.
- Social responsibility board of the Methodist Church: committee on health and healing.
- Secretary of the European Association for the Study of Diabetes’ workshop group: Artificial Insulin Delivery Systems and Pancreatic and Islet Transplantation.
- Chairman of Diabetes UK research grants committee
- Board of Trustees, Diabetes UK, by election
- Member Regional A+B award committee
- Consultant Physician, Oxford Radcliffe Hospital NHS Trust
Academic Awards (all awarded in open competition):
- Senior Scholar, Corpus Christi College, Oxford, 1970
- Medical Research Council Scholar, 1970
- Nuffield Junior Research Fellow, Balliol, Oxford, 1981
- Joan and Richard Doll Senior Research Fellow, Green College, 1984
- University of Oxford, Reader in Diabetic Medicine, 2000
- University of Oxford, Professor of Diabetic Medicine, 2002
Invited Lectures:
I have lectured widely, including many invited lectures and state-of-the-art lectures on the subjects of the World Pandemic of diabetes, insulin resistance and Γ-cell failure, mathematical modelling, the incretin axis and GLP-1, pulsatile insulin secretion, the aetiopathology of non-insulin-dependent diabetes, the analysis of pulsations in endocrinology, medical ethics, theology and chaos, lipids, and the care of the terminally ill. I gave the Banting Lecture at Diabetes UK (their most prestigious lecture) in 2010 on the subject of type 2 diabetes viewed as an infectious disease.
Academic Research Interests:
- The world pandemic of type 2 diabetes: founding director and trustee of the Oxford Health Alliance, a group co-ordinating activity in the prevention and containment of the epidemic.
- Type 2 diabetes: including mathematical modelling of insulin resistance and the analysis of pulsatile insulin (and other hormones, especially Growth Hormone) using time-series analysis.
- Insulin resistance and beta-cell failure: HOMA model of beta-cell function and insulin resistance: (described first by us in 1985) and now widely used in epidemiology and in 2013 iHOMA (Published in Diabetes Care)
- We have developed the concept of the Coefficient of failure to allow comparisons between trials aimed at preservation of beta-cell function
- Trials: deputy co-ordinator and member of the Executive and Policy Advisory Committees of the UK Prospective Study of Diabetes (UKPDS). Co-author on many major papers. The UKPDS is the basis for much of the evidence-base for the treatment of type 2 diabetes, and was the largest study in type 2 diabetes ever undertaken.
- Glucose and Ketone sensing in hand-held meters: our work is the basis of the published guidelines for home-ketone sensing.
- Therapeutic agents in type 2 diabetes: studies using sulphonylureas, thiazolidinediones, GLP-1, and insulin.
- Retinopathy: especially in type 2 diabetes.
- Dynamic insulin theory
- Long-acting and short-acting insulin in man
- Pulsatile insulin secretion in man
- We were the first group in the world to describe insulin oscillations using time-series analysis and pioneered the use of Fourier analysis in short signals for use in endocrinology research. We have now developed a suite of time-seris analysis programmes (Graph++) for use in this field.
- Growth Hormone secretion: its analysis and physiology.
- GLP-1 and the incretin axis.
- The history of diabetes an oral history project. Funded (twice) by the Wellcome trust
Academic and Clinical Work:
Teaching: Medical Tutor, Harris Manchester College.
Co-ordinator of several courses including the EASD Robert Turner Clinical Training course, and the Oxford Steno clinical training course.